货号：14-779

品牌：Merck Millipore

规格：1ea

目录价：￥5229.00

市场价格：￥4444.65

会员价格：￥4183.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: MKP5, active View All» Qty/Pk: 10 µg View All» Product Overview: Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both thephosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily(MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members ofthis family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissuedistribution and subcellular localization, and different modes of inducibility of their expression by extracellularstimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localizationis unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in varioustissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two differentisoforms have been found for this gene. View All» Key Applications: Phosphatase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Species: Human View All» Molecular Weight: 20.6 kDa View All» Quality Assurance: Routinely evaluated by the release of phosphate from the substrate 6,8-difluoro-4-methylumbelliferyl phosphate (DiFMUP) View All» Brand Family: Upstate View All» Source: N-terminal 6His-tagged, recombinant, human MKP5, amino acids 320-end, expressed in E. coli. View All» Presentation: Protein in 50 mM Tris/HCl pH 7.5, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution. View All» UniProt Number: Q9Y6W63 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Storage Conditions: 6 months at -70°C View All» Promotional Text: This enzyme is part of PhosphataseProfiler™, a custom inhibitor selectivity discovery service. View All» Packaging: Also available in 250μg size as catalog # 14-779M and in bulk as catalog # 14-779-K. View All» Gene Symbol:

• DUSP10

• MKP5
  View All» Product Name: MKP5, active View All» Entrez Gene Number: NM_007207 View All» Purification Method: Purified using Ni2+/NTA agarose. View All»
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