货号：14-756

品牌：Merck Millipore

规格：

目录价：￥4439.00

市场价格：￥3773.15

会员价格：￥3551.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: ACK1, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 10 μg View All» Product Overview: N-terminal GST-tagged recombinant, human ACK1, residues 1-389. View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. View All» UniProt Summary: FUNCTION: SwissProt: Q07912 # Downstream effector of CDC42 which mediates CDC42- dependent cell migration via phosphorylation of BCAR1. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR. Participates in clathrin-mediated endocytosis. May be involved both in adult synaptic function and plasticity and in brain development.COFACTOR: Magnesium.SIZE: 1036 amino acids; 114327 Da SUBUNIT: Interacts with CDC42. Interacts with activated CSPG4.SUBCELLULAR LOCATION: Cell membrane (By similarity).SIMILARITY: SwissProt: Q07912 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. & Contains 1 CRIB domain. & Contains 1 protein kinase domain. & Contains 1 SH3 domain. View All» Species: Human View All» Molecular Weight: 71.5 kDa View All» Brand Family: Upstate View All» Source: Expressed by baculovirus in Sf21 insect cells. View All» Protein Target: ACK1 View All» Storage Conditions: -70°C from date of shipment. View All» Target Sub-Family: TK View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Gene Symbol:

• TNK2

• FLJ44758

• ACK1

• p21cdc42Hs

• ACK

• ACK-1

• FLJ45547
  View All» Product Name: ACK1, active View All» Alternate Names: TNK2; ACK; FLJ44758; FLJ45547; p21cdc42Hs; tyrosine kinase, non-receptor, 2 View All» UniProt Number: Q07912 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Packaging: Also available in 250 μg size as catalog # 14-6756M - Call for pricing and availability. View All» Entrez Gene Number:
  • NM_001010938.1

  • NM_005781.4
    View All» Purification Method: Glutathione-agarose View All»
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