货号：14-743

品牌：Merck Millipore

规格：10Ug

目录价：￥5421.00

市场价格：￥4607.85

会员价格：￥4336.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: GCK, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 10 µg View All» Product Overview: N-terminal GST- tagged, recombinant, human GCK amino acids 1-473, expressed by baculovirus in Sf21 cells. View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. View All» UniProt Summary: FUNCTION: SwissProt: Q12851 # Enhances MAP3K1 oligomerization, which may relieve amino-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. May play a role in the regulation of vesicle targeting or fusion.COFACTOR: Magnesium.SIZE: 819 amino acids; 91586 Da SUBUNIT: Interacts with TRAF2, MAP3K1 and RAB8A.SUBCELLULAR LOCATION: Cytoplasm (By similarity). Basolateral cell membrane; Peripheral membrane protein (By similarity). Golgi apparatus membrane; Peripheral membrane protein (By similarity).TISSUE SPECIFICITY: Highly expressed in germinal center but not mantle zone B-cells. Also expressed in lung, brain and placenta and at lower levels in other tissues examined.SIMILARITY: SwissProt: Q12851 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. & Contains 1 CNH domain. & Contains 1 protein kinase domain. View All» Species: Human View All» Molecular Weight: 80.6 kDa. View All» Brand Family: Upstate View All» Source: Recombinant protein expressed in Sf21 cells View All» Protein Target: GCK View All» Storage Conditions: Stable for 6 months at -70 °C from date of shipment. For maximum recovery of product, centrifuge original vial prior to removing the cap. Rapidly thaw the vial under cold water and immediately place on ice. Aliquot unused material into pre-chilled microcentrifuge tubes and immediately snap-freeze the vials in liquid nitrogen prior to re-storage at -70 °C. View All» Target Sub-Family: STE View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Gene Symbol:

• MAP4K2

• GCK

• RAB8IP

• BL44
  View All» Product Name: GCK, active View All» Alternate Names: germinal center kinase View All» Quality Assurance: Routinely evaluated by phosphorylation of 0.8 mg/mL myelin basic protein. Purity was assessed by SDS-PAGE and Coomassie blue staining using 3 μg of active GCK. View All» UniProt Number: Q12851 View All» Specific Activity: 2337 U/mg, where one unit of GCK activity is defined as 1nmol phosphate incorporated into 0.8 mg/mL myelin basic protein per minute at 30°C with a final ATP concentration of 100 μM. View All» Entrez Gene Number: NM_004579.2 View All» Purification Method: Purified using glutathione-agarose. Purity 52% by SDS-PAGE and Coomassie blue staining. View All»
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