货号：14-735

品牌：Merck Millipore

规格：

目录价：￥3898.00

市场价格：￥3313.30

会员价格：￥3118.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: PDGFR α (550-end, V561D), active human View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 10 µg View All» Product Overview: N-terminal 6His-tagged, recombinant, human PDGFR alpha, amino acids 550 - end, containing the V561D mutation. This V561D mutation has been found in some patients with gastrointestinal stromal tumors and confers constitutive activity (Hirota S et al., Gastroenterology (2003); 125:660-667 and Lasota, J. et al., Laboratory Investigation (2004): 84: 874-883). View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes. View All» UniProt Summary: FUNCTION: SwissProt: P16234 # Receptor that binds both PDGFA and PDGFB and has a tyrosine-protein kinase activity.SIZE: 1089 amino acids; 122670 Da SUBUNIT: Homodimer, and heterodimer with PDGFRB. Interacts with SHB (By similarity).SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.DISEASE: SwissProt: P16234 # A fusion of PDGFRA and FIP1L1 (FIP1L1-PDGFRA), due to an interstitial chromosomal deletion, is the cause of some cases of hypereosinophilic syndrome (HES) [MIM:607685]. HES is a rare hematologic disorder characterized by sustained overproduction of eosinophils in the bone marrow, eosinophilia, tissue infiltration and organ damage.SIMILARITY: SwissProt: P16234 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 5 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain. View All» Species: Human View All» Molecular Weight: 63.5 kDa View All» Brand Family: Upstate View All» Source: Expressed by baculovirus in Sf21 cells. View All» Presentation: 10 μg of recombinant protein in 100 μL of 50 mM Tris-HCl pH 7.5, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution. View All» Protein Target: PDGFRα View All» Storage Conditions: Storage and Stability: Stable for 6 months at -70 °C from date of shipment. For maximum recovery of product, centrifuge original vial prior to removing the cap. Rapidly thaw the vial under cold water and immediately place on ice. Aliquot unused material into pre-chilled microcentrifuge tubes and immediately snap-freeze the vials in liquid nitrogen prior to re-storage at -70°C. View All» Target Sub-Family: TK View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Gene Symbol:

• PDGFRA

• CD140a

• PDGF-R-alpha

• MGC74795

• PDGFR2

• Rhe-PDGFRA

• CD140A
  View All» Product Name: PDGFR α (550-end, V561D), active human View All» Alternate Names: platelet derived growth factor receptor, alpha polypeptide View All» Quality Assurance: Routinely evaluated by phosphorylation 250 μM GGMEDIYFEFMGGKKK. Purity was assessed by SDS-PAGE and Coomassie blue staining using 3 μg of active PDGFR alpha. View All» UniProt Number: P16234 View All» Specific Activity: 979 U/mg, where one unit of PDGFR alpha (V561D) activity is defined as 1nmol phosphate incorporated into 250 μM GGMEDIYFEFMGGKKK per minute at 30°C with a final ATP concentration of 100 μM. View All» Entrez Gene Number: NM_006206.3 View All» Purity: Purity 81% by SDS-PAGE and Coomassie blue staining. View All» Purification Method: Ni²⁺/NTA-agarose View All»
  © 金山科研平台是专业的授权总代理区域代理经销平台。
  © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
  © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
  © 本文地址：https://16ao.com/thread-145772.htm
  © Merck Millipore代理14-735 PDGFRa (550-end,V561D) active hu 10ug，产品报价联系微信jinshanbio