货号：14-718M

品牌：Merck Millipore

规格：

目录价：￥35739.00

市场价格：￥30378.15

会员价格：￥28591.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: CaM Kinase IIβ, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 250 μg View All» Product Overview: N-terminal 6His-tagged, recombinant, CaM Kinase IIβ, amino acids 1-315 View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Eight transcript variants encoding eight distinct isoforms have been identified for this gene. View All» UniProt Summary: FUNCTION: SwissProt: Q13554 # CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity).SIZE: 664 amino acids; 72727 Da SUBUNIT: CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Interacts with SYNGAP1 (By similarity). Interacts with MPDZ.TISSUE SPECIFICITY: Widely expressed. Expressed in adult and fetal brain. Expression islightly lower in fetal brain.SIMILARITY: SwissProt: Q13554 ## Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. & Contains 1 protein kinase domain. View All» Species: Human View All» Molecular Weight: 39.6kDa View All» Brand Family: Upstate View All» Source: expressed by baculovirus in Sf21 cells View All» Protein Target: CaMKIIβ View All» Storage Conditions: 6 months at -70°C from date of shipment View All» Target Sub-Family: CAMK View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Gene Symbol:

• CAMK2B

• CAMKB

• CAM2

• MGC29528

• CAMK2
  View All» Product Name: CaM Kinase IIβ, active View All» Quality Assurance: Routinely evaluated by phosphorylation of 250μM ZIPtide (Catalog # 12-545) View All» UniProt Number: Q13554 View All» Packaging: Also available in 10 μg size (cat#14-718) and in bulk (cat#14-718-K). View All» Entrez Gene Number:
  • NM_001220.3

  • NM_172078.1

  • NM_172079.1

  • NM_172080.1

  • NM_172081.1

  • NM_172082.1

  • NM_172083.1

  • NM_172084.1
    View All» Purification Method: Ni²⁺/NTA-agarose View All»
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