R&D Systems代理AF840 Human IL-18 R alpha/IL-1 R5 Affinity Purified Polyclonal Ab (100 UG)-试剂-金山科研平台

R&D Systems代理AF840 Human IL-18 R alpha/IL-1 R5 Affinity Purified Polyclonal Ab (100 UG)

2025-06-25

货号：AF840

品牌：R&D Systems

规格：100ug

目录价：￥5040.00

市场价格：￥4032.00

会员价格：￥4032.00

到货时间：3~4周

金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: IL-18 R alpha/IL-1 R5 Long Name: Interleukin 18 Receptor alpha Aliases: CD218a; IL-1 R5; IL-1 Rrp; IL-18 R1; IL18R1 Entrez Gene IDs: 8809 (Human); 16174 (Mouse) Background: IL-18 R alpha

View IL-18 R alpha IHC images. Interleukin-18 (IL-18) is a member of the IL-1 family of cytokines and shares numerous immuno-regulatory functions with IL-12. The functional IL-18 receptor complex is composed of two subunits designated IL18 R alpha (also termed IL-1 R5 and IL-1 Rrp) and IL-18 R beta (also termed IL-1 R7 and AcPL). Both IL-18 R alpha and IL-18 R beta belong to the IL-1 receptor superfamily. Although IL-18 R by itself binds IL-18 with low affinity and IL-18 R beta does not bind IL18 in vitro, coexpression of IL-18 R alpha and IL18 R beta is required for high affinity binding and IL-18 responsiveness.

Human IL-18 R cDNA encodes a 541 amino acid (aa) precursor type I membrane protein with a hydrophobic signal, an extracellular domain comprised of three immunoglobulin-like domains, a transmembrane domain and a cytoplasmic region of approximately 200 aa residues. Human and mouse IL-18 R share 65% amino acid sequence homology. IL-18 R is widely expressed in numerous tissues including spleen, thymus, leukocyte, liver, lung, heart, small and large intestine, prostate and placenta.

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