金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: VEGF R3/Flt-4 Long Name: Vascular Endothelial Growth Factor Receptor 3 Aliases: FLT4; Flt-4 Entrez Gene IDs: 2324 (Human); 14257 (Mouse) Background: VEGF R1, R3

VEGF R1 (Flt-1), VEGF R2 (KDR/Flk-1), and VEGF R3 (Flt-4) belong to the class III subfamily of receptor tyrosine kinases (RTKs). All three receptors contain seven immunoglobulin-like repeats in their extracellular domain and kinase insert domains in their intracellular region. They are best known for regulating VEGF family-mediated vasculogenesis, angiogenesis, and lymphangiogenesis. They are also mediators of neurotrophic activity and regulators of hematopoietic development. VEGF R2 is thought to be the primary inducer of VEGF-mediated blood vessel growth, while VEGF R3 plays a significant role in VEGF-C and VEGF-D-mediated lymphangiogenesis.