金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: FCRN Long Name: Neonatal Fc Receptor Aliases: FCGRT Entrez Gene IDs: 2217 (Human); 14132 (Mouse); 29558 (Rat) Background: FCRN The neonatal Fc receptor (FCRN) is widely expressed in endothelial and epithelial cells and plays an important role in IgG homeostasis. Mouse FCRN binds with high affinity to IgG from mouse, human, rat, rabbit, guinea pig, bovine, and sheep, while human FCRN binds IgG with significantly lower affinity and is much more restricted in terms of species recognition. FCRN additionally binds to albumin, and both it and IgG are bound at pH 5.0 but not at pH 8.0. It binds endocytosed IgG and albumin in the low pH vesicles and transports them to the plasma membrane for extracellular release at higher pH. This mechanism is involved in the bidirectional transport of IgG across epithelial and endothelial barriers including neonatal IgG absorption in the intestine and fetal uptake of maternal antibodies through the placenta.