金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: PIWIL1/HIWI Long Name: Piwi-like Protein 1 Aliases: HIWI; MIWI Entrez Gene IDs: 9271 (Human) Background: PIWIL1 PIWIL1 (piwi-like 1), also called HIWI (human homolog of drosophila piwi), is a cytoplasmic protein of the PIWI subgroup of the Argonaute family. PIWI domains bind a class of ~29-30 nucleotide RNAs termed piRNAs (piwi domain-binding RNAs). PIWIL1 orthologs are expressed with piRNAs in germ cells and are essential for spermatogenesis in mice. CD34+ hematopoietic progenitor cell PIWIL1 is downregulated upon differentiation. When overexpressed in leukemic cell lines, PIWIL1 inhibits growth and induces apoptosis.