金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: Cytosolic Sulfotransferase 1A1/SULT1A1 Aliases: P-PST; PST; ST1A3; STP1 ; SULT1A1; TSPST1 Entrez Gene IDs: 6817 (Human); 20887 (Mouse); 83783 (Rat) Background: Cytosolic Sulfotransferase 1A1 Cytosolic sulfotransferases catalyze the sulfonation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. They are distinct from Golgi resident sulfotransferases by the absence of transmembrane domains and are located in the cytoplasm. SULT1A1 is one of two phenol sulfotransferases with thermostable enzyme activity. The enzyme is more specific for sulfonation on catecholamines, phenolic drugs and neurotransmitters. Because of its ability to modify diverse promutagen and procarcinogen xenobiotics, it is implicated in a range of cancers. The crystal structure of the enzyme reveals that its active site is flexible and can accommodate diverse hydrophobic substrates with varying sizes, shapes and flexibility.