R&D Systems代理AF5360 Human/Mouse Neuroplastin 65 Affinity Purified Polyclonal Ab (100 UG)

2025-06-25

货号:AF5360

品牌:R&D Systems

规格:100ug

目录价:¥5040.00

市场价格:¥4032.00

会员价格:¥4032.00

  • 到货时间:3~4周

    金山科研平台,产品价格货期咨询微信:jinshanbio Molecule Information: Neuroplastin 65 Aliases: Np65 Entrez Gene IDs: 27020 (Human); 56064 (Rat) Background: Neuroplastin 65

    View Neuroplastin 65 IHC images. Neuroplastin (NPTN; also stromal cell-derived receptor 1 and Np55) is a 52 - 57 kDa member of the Ig-superfamily. Neuroplastin is widely expressed and likely serves as a cell adhesion molecule in multiple tissues. Human Neuroplastin is 282 amino acids (aa) in length. It is a type I transmembrane glycoprotein that contains two Ig-like domains (aa 32 - 119 and 122 - 213) and a 38 aa cytoplasmic region (aa 245 - 282).

    There is a brain-enriched 65 kDa form of Neuroplastin 65 (Np65) that negatively regulates LTP in the hippocampus. Neuroplastin 65 contains an N-terminal 116 aa Ig-like domain-containing insert after Asn30 and interacts homotypically. Notably, human and rodent Np65 expression patterns are different in brain, with rodent Np65 not predominating in cerebellum. Over aa 29 - 336, human Np65 is 95% aa identical to mouse Np65.

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