金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: APLP-2 Long Name: Amyloid Beta [A4] Precursor-like Protein 2 Aliases: APPH; APPL2; CDEBP; WALPLP2; YWK-II Entrez Gene IDs: 334 (Human); 11804 (Mouse); 64312 (Rat) Background: APLP-2 Amyloid beta precursor-like protein 2 (APLP-2) is a 120-170 kDa member of the APP family of neuronal type I transmembrane proteins. Its extracellular domain consists of an N-terminal Cys-rich domain, an Asp/Glu-rich acidic region, a Kunitz protease inhibitor (KPI) domain, and a GAG attachment site in the membrane proximal domain. APLP-2 forms both homodimers and heterodimers with APP and APLP-1. Proteolytic cleavage of APLP-2 generates peptides similar to the amyloidogenic A beta peptides and a cytoplasmic fragment that functions as a transcriptional coactivator. Alternate splicing of APLP-2 generates isoforms that lack the KPI domain or contain an insertion that prevents GAG attachment. The extracellular domain of human APLP-2 shares 81% and 93% aa sequence identity with mouse and rat APLP-2, respectively.