金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: Nbs1 Long Name: Nijmegen Breakage Syndrome 1 Aliases: NBN; Nibrin; p95 Entrez Gene IDs: 4683 (Human); 27354 (Mouse); 85482 (Rat) Background: Nbs1 The Nijmegen Breakage Syndrome 1 (Nbs1) protein is a member of the Mre11/Rad50/Nbs1 (MRN) protein complex that binds to DNA double-strand breaks in cells exposed to DNA damaging agents. In addition, the MRN complex colocalizes with replication forks during DNA replication. The MRN complex plays an important role in routine cell cycle progression and genotoxic stress responses by facilitating DNA repair. In fact, mutation of the nbs1 gene and resultant loss of Nbs1 protein expression in humans results in the chromosomal instability disease, Nijmegen Breakage Syndrome.