金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: CTLA-4 Long Name: Cytotoxic T-lymphocyte-associated Molecule 4 Aliases: CD152 Entrez Gene IDs: 1493 (Human); 12477 (Mouse) Background: CTLA-4 CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. CTLA-4 is up-regulated rapidly following T cell activation and CD28 ligation. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28.