金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: PP1 Inhibitor-2 Long Name: Protein Phosphatase 1 Inhibitor 2 Aliases: IPP2; PPP1R2 Entrez Gene IDs: 5504 (Human); 66849 (Mouse); 192361 (Rat) Background: PP1 Inhibitor-2 Protein Phosphatase 1 Inhibitor-2 (PP1 Inhibitor-2), also called PP1 regulatory subunit 2 (PP1R2), I2, and IPP2, binds to PP1 through an RVxF consensus sequence. The complex inactivates PP1, preventing it from dephosphorylating substrates such as glycogen phosphorylase. Unlike PP1 Inhibitor-1, the binding of PP1 Inhibitor-2 is Protein Kinase A phosphorylation-independent. Dissociation of the PP1 Inhibitor-2 complex is enhanced by phosphorylation at T72 by GSK-3, ERK, or CDK. Overexpression of PP1 Inhibitor-2 in mouse heart improves cardiac function without changing organ size.