金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: NPR-1 Long Name: Natriuretic Peptide Receptor A Aliases: ANPa; ANPRA; GC-A; GUCY2A; NPRA; Pndr Entrez Gene IDs: 4881 (Human); 18160 (Mouse); 24603 (Rat) Background: NPR1 Natriuretic peptide receptor A/guanylate cyclase A (NPR-1), also called NPRA or GC-A, is a 120 - 140 kDa type I transmembrane glycoprotein that is the primary receptor for natrietic peptides ANP and BNP. Binding of ANP to the extracellular ligand binding domain (aa 54 - 415), plus ATP to the intracellular kinase homology domain (aa 528 - 805) activates a cytoplasmic guanylate cyclase (aa 840 - 1023). NPR-1 is expressed most highly in kidney, adrenal and adipose tissue. Human NPR-1 extracellular domain shows 86%, 44% and 34% aa identity with mouse NPR-1, human NPRB and human NPRC, respectively.