R&D Systems代理AF3898 Human Calreticulin Affinity Purified Polyclonal Ab (100 UG)-试剂-金山科研平台

R&D Systems代理AF3898 Human Calreticulin Affinity Purified Polyclonal Ab (100 UG)

2025-06-25

货号：AF3898

品牌：R&D Systems

规格：100ug

目录价：￥5040.00

市场价格：￥4032.00

会员价格：￥4032.00

到货时间：3~4周

金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: Calreticulin Aliases: Autoantigen Ro; CALR; Calregulin; cC1qR; CRT; SSA; Vasostatin Entrez Gene IDs: 811 (Human); 12317 (Mouse); 64202 (Rat) Background: Calreticulin

View Calreticulin IHC images. Calreticulin is a multifunctional, intracellular calcium-binding protein that is found in most eukaryotic cells. It serves as a key regulator of intracellular free calcium levels. Calreticulin also functions as a lectin-type chaperone in the endoplasmic reticulum (ER). It binds to oligosaccharide residues on newly synthesized glycoproteins to ensure proper folding and retains non-native protein conformers within the ER where they are targeted for degradation. Calreticulin has also been characterized as an inhibitor of steroid hormone-regulated gene expression. Its N-terminal domain, which is termed Vasostatin, binds to the KxFFKR motif located in the DNA-binding domain of nuclear hormone receptors, preventing the receptors from binding to their specific recognition sequence. Additionally, Calreticulin is thought to function as an extracellular lectin and an intracellular mediator of integrin-dependent cell adhesion.

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