金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: CD74 Aliases: CD74; CLIP; DHLAG; HLADG; Ia-gamma; INVG34 Entrez Gene IDs: 972 (Human); 16149 (Mouse); 25599 (Rat) Background: CD74 CD74 is a transmembrane protein which, on antigen presenting cells, is the invariant chain that chaperones MHC class II dimers from the endoplasmic reticulum to the cell surface. The cytoplasmic portion of CD74 can be released by intramembrane cleavage to activate NFkB. CD74 is upregulated in several cancers and is also expressed by non-immune cells during inflammation.