金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: MEPE/OF45 Long Name: Matrix Extracellular Phosphoglycoprotein with ASARM Motif Aliases: OF45; Osteoregulin Entrez Gene IDs: 56955 (Human); 94111 (Mouse); 79110 (Rat) Background: MEPE MEPE, known as OF45 in mouse and rat, is a 55 kDa member of the SIBLING protein family that is primarily expressed in bone and dentin where it regulates the mineralization of those tissues. MEPE is secreted by osteoblasts and dental pulp stem cells during the mineralization process and also by non-mineralizing tissues including epithelial cells in the renal proximal tubule and salivary duct. MEPE contains multiple consensus sites for post-translational modifications, including N-linked glycosylation, N-myristoylation, glycosaminoglycan attachment, and phosphorylation by a variety of kinases. MEPE also contains several putative proteolytic cleavage sites and one integrin-binding RGD motif.