金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: TRH-degrading Ectoenzyme/TRHDE Long Name: Thyrotropin Releasing Hormone-degrading Ectoenzyme Aliases: PAP-II; PGPEP2; Thyroliberinase; TRHDE; TRH-DE Entrez Gene IDs: 29953 (Human); 237553 (Mouse) Background: TRH-degrading Ectoenzyme/TRHDE TRHDE is a metalloprotease that specifically removes pyroglutamate from thyrotropin-releasing hormone (TRH). TRH functions as a hypothalamic hypophysiotropic neuropeptide and neurotransmitter/neuromodulator within the central nervous system. Because TRHDE inactivates TRH, TRHDE inhibitors have potential applications as research and therapeutic agents. TRHDE is a type II transmembrane protein and a soluble form is also present in the serum.