金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: Sulfatase Modifying Factor 2/SUMF2 Aliases: FGE2 Entrez Gene IDs: 25870 (Human) Background: Sulfatase Modifying Factors Mammalian sulfatases have a common CXPXR motif, in which the Cys residue is post-translationally modified to a Calpha-formylglycine (FGly) residue. This modification is essential for catalytic activity of all sulfatases and is catalyzed by FGly generating enzyme (FGE) encoded by sulfatase modifying factor 1 (SUMF1). FGE deficiency causes multiple sulfatase deficiency (MSD), a rare autosomal recessive disorder. SUMF2 does not have FGly enzymatic activity, but may compete with SUMF1 for the same substrate.