金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: Insulin R/IGF-I R Heterotetramer Long Name: Insulin Receptor Background: Insulin R/IGF-I R Heterotetramer The heterotetrameric receptors for insulin (INS R) and IGF-I (IGF-I R) are receptor tyrosine kinases that consist of two ligandbinding alpha subunits and two beta subunits. Ligand binding induces autophosphorylation on multiple tyrosine residues of beta subunits. Phosphorylation of Tyr1162 and 1163 on INS R and Tyr1135 and 1136 on IGF-I R stimulates intrinsic kinase activity.