金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: Chk1 Long Name: Checkpoint Kinase 1 Aliases: CHEK1 Entrez Gene IDs: 1111 (Human); 12649 (Mouse); 140583 (Rat) Background: Chk1 The Chk1 checkpoint kinase is an integral member of the signaling cascade that controls cell cycle progression. In response to genotoxic stress, Chk1 is phosphorylated by ATM or ATM-related kinases. In turn, Chk1 phosphorylates downstream effectors, such as p53 or the Cdc25 phosphatases to halt cell cycle progression and allow time for repair of incurred damage.