货号：14-614

品牌：Merck Millipore

规格：10Ug

目录价：￥5382.00

市场价格：￥4574.70

会员价格：￥4305.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: ALK4, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 10 µg View All» Product Overview: N-terminal GST-tagged, recombinant, human ALK4 amino acids 150-end. View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type IB receptor, composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed. View All» UniProt Summary: FUNCTION: SwissProt: P36896 # On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators.COFACTOR: Magnesium or manganese (By similarity).SIZE: 505 amino acids; 56807 Da SUBUNIT: Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3 (By similarity).SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver.SIMILARITY: SwissProt: P36896 ## Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. & Contains 1 GS domain. & Contains 1 protein kinase domain. View All» Species: Human View All» Molecular Weight: 63.8kDa View All» Brand Family: Upstate View All» Source: Human ALK4 expressed by baculovirus in Sf21 insect cells. View All» Protein Target: ALK4 View All» Storage Conditions: 6 months at -70°C from date of shipment View All» Target Sub-Family: TKL View All» Gene Symbol:

• ACVR1B

• ALK-4

• ACVRLK4

• ALK4

• SKR2

• ActRIB

• ACTR-IB

• ACTRIB
  View All» Product Name: ALK4, active View All» Quality Assurance: routinely evaluated by phosphorylation of casein. View All» UniProt Number: P36896 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Entrez Gene Number:
  • NM_004302.3

  • NM_020327.2

  • NM_020328.2
    View All» Purification Method: Glutathione-agarose View All»
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