货号：14-612

品牌：Merck Millipore

规格：10Ug

目录价：￥6618.00

市场价格：￥5625.30

会员价格：￥5294.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: RIPK2, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 10 µg View All» Product Overview: human RIPK2, amino acids 1-299 View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. View All» UniProt Summary: FUNCTION: SwissProt: O43353 # Activates pro-caspase-1 and pro-caspase-8. Potentiates CASP8-mediated apoptosis. Activates NF-kappa-B.SIZE: 540 amino acids; 61195 Da SUBUNIT: Binds to CFLAR/CLARP and CASP1 via their CARD domains. Binds to BIRC3/c-IAP1 and BIRC2/c-IAP2, TRAF1, TRAF2, TRAF5 and TRAF6. May be a component of both the TNFRSF1A and TNRFSF5/CD40 receptor complex.SUBCELLULAR LOCATION: Cytoplasm (Probable).TISSUE SPECIFICITY: Detected in heart, brain, placenta, lung, peripheral blood leukocytes, spleen, kidney, testis, prostate, pancreas and lymph node.PTM: Autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.SIMILARITY: SwissProt: O43353 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. & Contains 1 CARD domain. & Contains 1 protein kinase domain. View All» Species: Human View All» Molecular Weight: 37.8kDa View All» Brand Family: Upstate View All» Source: N-terminal His6-tagged, recombinant, human RIPK2 expressed by baculovirus in Sf21 insect cells View All» Protein Target: RIPK2 View All» Storage Conditions: 6 months at -70°C View All» Target Sub-Family: TKL View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Gene Symbol:

• RIPK2

• RIP2

• GIG30

• RICK

• CARDIAK

• CARD3

• CCK

• RIP-2
  View All» Product Name: RIPK2, active View All» Quality Assurance: routinely evaluated by phosphorylation of MBP View All» UniProt Number: O43353 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Entrez Gene Number: NM_003821.5 View All» Purification Method: Ni²⁺/NTA-agarose View All»
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