货号：14-608

品牌：Merck Millipore

规格：10Ug

目录价：￥5382.00

市场价格：￥4574.70

会员价格：￥4305.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: ZIPK, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 10 µg View All» Product Overview: N-terminal, GST tagged, recombinant, of human ZIPK amino acids 1-290 View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis. View All» UniProt Summary: FUNCTION: SwissProt: O43293 # Serine/threonine kinase which acts as a positive regulator of apoptosis. Phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis.COFACTOR: Magnesium.SIZE: 454 amino acids; 52536 Da SUBUNIT: Homodimer or forms heterodimers with ATF4. Both interactions require an intact leucine zipper domain and oligomerization is required for full enzymatic activity. Also binds to DAXX and PAWR, possibly in a ternary complex which plays a role in caspase activation. Interacts with AATF and CDC5L.SUBCELLULAR LOCATION: Nucleus. Cytoplasm (By similarity). Note=Relocates to the cytoplasm on binding PAWR where the complex appears to interact with actin filaments (By similarity). Associates to centromeres from prophase to anaphase.SIMILARITY: SwissProt: O43293 ## Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily. & Contains 1 protein kinase domain. View All» Species: Human View All» Molecular Weight: 64.3kDa View All» Brand Family: Upstate View All» Source: expressed in E. coli View All» Protein Target: ZIPK View All» Storage Conditions: 6 months at -70°C View All» Target Sub-Family: CAMK View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Gene Symbol:

• DAPK3

• FLJ36473

• ZIP-kinase

• ZIPK

• Dlk

• ZIP
  View All» Product Name: ZIPK, active View All» Quality Assurance: routinely evaluated by phosphorylation of 250μM ZIPtide View All» UniProt Number: O43293 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Entrez Gene Number: NM_001348.1 View All» Purification Method: Glutathione agarose affinity chromatography View All»
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