货号：14-600M

品牌：Merck Millipore

规格：600M

目录价：￥38338.64

市场价格：￥32587.84

会员价格：￥30670.91

金山科研平台，产品价格货期咨询微信：jinshanbio Description: TAK1-TAB1 fusion, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 250 µg View All» Product Overview: N-terminal His6-tagged, recombinant, human TAK1 amino acids 1-303, fused to human TAB1 amino acids 437-end View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. View All» UniProt Summary: FUNCTION: SwissProt: O43318 # Component of a protein kinase signal transduction cascade. Mediator of TGF-beta signal transduction. Stimulates NF- kappa-B activation and the p38 MAPK pathway.COFACTOR: Magnesium.SIZE: 606 amino acids; 67196 Da SUBUNIT: Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts with MAP3K7IP1 and MAP3K7IP2. Interacts with PPM1L.PTM: Association with MAP3K7IP1 promotes autophosphorylation and subsequent activation.SIMILARITY: SwissProt: O43318 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. & Contains 1 protein kinase domain. View All» Species: Human View All» Molecular Weight: 42.8kDa View All» Brand Family: Upstate View All» Source: expressed by baculovirus in Sf21 insect cells View All» Protein Target: Tak1 View All» Storage Conditions: 6 months at -70°C View All» Target Sub-Family: TKL View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Gene Symbol:

• MAP3K7

• TAK1

• TGF1a
  View All» Product Name: TAK1-TAB1 fusion, active View All» Quality Assurance: routinely evaluated by phosphorylation of casein View All» UniProt Number: O43318 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Packaging: Also available in 10 μg size (cat#14-600) and in bulk (cat# 14-600-K). View All» Entrez Gene Number:
  • NM_003188.2

  • NM_145331.1

  • NM_145332.1

  • NM_145333.1
    View All» Purification Method: Ni²⁺/NTA-agarose View All»
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