货号：14-573

品牌：Merck Millipore

规格：10Ug

目录价：￥6586.00

市场价格：￥5598.10

会员价格：￥5268.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Pim1, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 10 µg View All» Product Overview: N-terminal GST-tagged recombinant human full length Pim-1 View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: The protooncogene PIM1 encodes a protein kinase upregulated in prostate cancer (Dhanasekaran et al., 2001 [PubMed 11518967]).[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: P11309 # Plays a role in signal transduction in blood cells. Contributes to both cell proliferation and survival and thus provide a selective advantage in tumorigenesis. May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3.COFACTOR: Manganese.SIZE: 404 amino acids; 45412 Da SUBUNIT: Binds to RP9. Isoform 2 is isolated as a monomer whereas isoform 1 complexes with other proteins. Isoform 1, but not isoform 2, binds BMX.SUBCELLULAR LOCATION: Isoform 2: Cytoplasm. Nucleus. & Isoform 1: Cell membrane.TISSUE SPECIFICITY: Expressed primarily in cells of the hematopoietic and germline lineages. Isoform 1 and isoform 2 are both expressed in prostate cancer cell lines.PTM: Autophosphorylated on both serine/threonine and tyrosine residues.SIMILARITY: SwissProt: P11309 ## Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. & Contains 1 protein kinase domain. View All» Species: Human View All» Molecular Weight: 62kDa View All» Brand Family: Upstate View All» Source: expressed in E. coli cells View All» Protein Target: Pim-1 View All» Storage Conditions: 6 months at -70°C View All» Target Sub-Family: CAMK View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Gene Symbol:

• PIM1

• PIM
  View All» Product Name: Pim1, active View All» Quality Assurance: routinely evaluated by phosphorylation of S6 Kinase/Rsk-2 Substrate Peptide 2 View All» UniProt Number: P11309 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Packaging: Also available in 250 µg size --call for pricing and availability and reference catalog number 14-573M when ordering the 250 µg size. View All» Entrez Gene Number: NM_002648.2 View All» Purification Method: Glutathione agarose affinity chromatography View All»
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