货号：14-553M

品牌：Merck Millipore

规格：1ea

目录价：￥42566.00

市场价格：￥36181.10

会员价格：￥34052.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: EphB2, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 250 µg View All» Product Overview: N-terminal His6-tagged recombinant human EphB2 residues 560-end View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members. View All» UniProt Summary: FUNCTION: SwissProt: P29323 # Receptor for members of the ephrin-B family. Acts as a tumor suppressor.SIZE: 1055 amino acids; 117493 Da SUBUNIT: The ligand-activated form interacts with multiple proteins, including GTPase-activating protein (RASGAP) through its SH2 domain. Binds RASGAP through the juxtamembrane tyrosines residues. Interacts with PRKCABP and GRIP1 (By similarity).SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Brain, heart, lung, kidney, placenta, pancreas, liver and skeletal muscle. Preferentially expressed in fetal brain.DISEASE:SwissProt: P29323 # Defects in EPHB2 are involved in the progression of prostate cancer [MIM:176807]. & Defects in EPHB2 are involved in the development of prostate cancer metastasis to the brain [MIM:603688].SIMILARITY: SwissProt: P29323 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. & Contains 2 fibronectin type-III domains. & Contains 1 protein kinase domain. & Contains 1 SAM (sterile alpha motif) domain. View All» Species: Human View All» Molecular Weight: 52kDa View All» Brand Family: Upstate View All» Source: Human EphB2 expressed by baculovirus in Sf21 insect cells View All» Protein Target: EphB2 View All» Storage Conditions: 6 months at -70°C View All» Target Sub-Family: TK View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Gene Symbol:

• EPHB2

• EphB2

• CAPB

• EPHT3

• Hek5

• DRT

• EPTH3

• TYRO5

• ERK

• HEK5

• MGC87492

• PCBC

• Tyro5
  View All» Product Name: EphB2, active View All» Quality Assurance: Routinely evaluated by phosphorylation of Poly (Glu4-Tyr) (4:1) View All» UniProt Number: P29323 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Packaging: Also available in 10 μg size (cat#14-553) and in bulk (cat# 14-553-K). View All» Entrez Gene Number:
  • NM_004442.6

  • NM_017449.3
    View All» Purification Method: Ni²⁺/NTA-agarose View All»
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