货号：14-546

品牌：Merck Millipore

规格：

目录价：￥5300.00

市场价格：￥4505.00

会员价格：￥4240.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: G9a, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 50 µg View All» Product Overview: Recombinant fusion protein containing amino acids 785-1210 of human G9a with an N-terminal GST tag View All» Key Applications: Histone Methyltransferase Assay (HMT) View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. This gene is found near this cluster; it was mapped near the gene for C2 within a 120-kb region that included a HSP70 gene pair. These genes are all within the human major histocompatibility complex class III region. This gene was thought to be two different genes, NG36 and G9a, adjacent to each other but a recent publication shows that there is only a single gene. The protein encoded by this gene is thought to be involved in intracellular protein-protein interaction. There are three alternatively spliced transcript variants of this gene but only two are fully described. View All» UniProt Summary: FUNCTION: SwissProt: Q96KQ7 # Histone methyltransferase. Preferentially methylates 'Lys-9' of histone H3 and 'Lys-27' of histone H3 (in vitro). H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. Also methylates histone H1 (By similarity).SIZE: 1210 amino acids; 132370 Da SUBUNIT: Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Interacts with GFI1B, WIZ and EHMT1.SUBCELLULAR LOCATION: Nucleus. Note=Associates with euchromatic regions. Does not associate with heterochromatin.TISSUE SPECIFICITY: Expressed in all tissues examined, with high levels in fetal liver, thymus, lymph node, spleen and peripheral blood leukocytes and lower level in bone marrow.DOMAIN:SwissProt: Q96KQ7 The SET domain mediates interaction with WIZ.PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.SIMILARITY: Belongs to the histone-lysine methyltransferase family. Suvar3-9 subfamily. & Contains 7 ANK repeats. & Contains 1 post-SET domain. & Contains 1 pre-SET domain. & Contains 1 SET domain. View All» Species: Human View All» Molecular Weight: ~78kDa View All» Brand Family: Upstate View All» Source: expressed in E. coli View All» Storage Conditions: 6 months at -20°C View All» Gene Symbol:

• EHMT2

• G9A

• NG36/G9a

• Em:AF134726.3

• C6orf30

• BAT8

• NG36

• FLJ35547
  View All» Product Name: G9a, active View All» Quality Assurance: routinely evaluated by methylazation of core histones View All» UniProt Number: Q96KQ7 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Entrez Gene Number:
  • NM_006709.2

  • NM_025256.4
    View All» Purification Method: Glutathione agarose affinity chromatography View All»
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