货号：14-544M

品牌：Merck Millipore

规格：1ea

目录价：￥42566.00

市场价格：￥36181.10

会员价格：￥34052.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: PAR-1Bα, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 250 µg View All» Product Overview: N-terminal His6-tagged, recombinant, full-length, human PAR-1B alpha View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: EMK (ELKL Motif Kinase) is a small family of ser/thr protein kinases involved in the control of cell polarity, microtubule stability and cancer. Several cDNA clones have been isolated that encoded two isoforms of the human ser/thr protein kinase EMK1. These isoforms were characterized by the presence of a 162-bp alternative exon that gave rise to two forms, one containing the exon and the other one lacking it. Both forms were found to be coexpressed in a number of selected cell lines and tissue samples. The human EMK1 was shown to be encoded by a single mRNA ubiquitously expressed. View All» UniProt Summary: FUNCTION: SwissProt: Q7KZI7 # Role in epithelial morphogenesis. Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. One or more isoforms may play a role in graft rejection.COFACTOR: Magnesium.SIZE: 788 amino acids; 87911 Da SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. Note=Phosphorylated by PRKCZ in polarized epithelial cells, resulting in an interaction with YWHAZ which promotes relocation from the lateral to the apical membrane.TISSUE SPECIFICITY: High levels of expression in heart, brain, skeletal muscle and pancreas, lower levels observed in lung, liver and kidney.SIMILARITY: SwissProt: Q7KZI7 ## Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. MARK subfamily. & Contains 1 KA1 (kinase-associated) domain. & Contains 1 protein kinase domain. & Contains 1 UBA domain. View All» Species: Human View All» Molecular Weight: 81.6kDa View All» Brand Family: Upstate View All» Source: expressed by baculovirus in SF21 insect cells View All» Protein Target: PAR-1Ba View All» Storage Conditions: 6 months at -70°C View All» Target Sub-Family: CAMK View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Gene Symbol:

• MARK2

• MGC99619

• EMK1

• PAR-1
  View All» Product Name: PAR-1Bα, active View All» Quality Assurance: routinely evaluated by phosphorylation of CHKtide View All» UniProt Number: Q7KZI7 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Packaging: Also available in 10 μg size (cat#14-544) and in bulk (cat# 14-544-K). View All» Entrez Gene Number:
  • NM_001039468.1

  • NM_001039469.1

  • NM_004954.3

  • NM_017490.2
    View All» Purification Method: Ni²⁺/NTA-agarose View All»
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