货号:14-499
品牌:Merck Millipore
规格:10Ug
目录价:¥6586.00
市场价格:¥5598.10
会员价格:¥5268.80
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Description:
Bmx, active
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Trade Name:
Upstate (Millipore)
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Qty/Pk:
10 µg
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Product Overview:
N-terminal His6 tagged, recombinant, full length, human Bmx
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Key Applications:
Kinase Assay
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Entrez Gene Summary:
Tyrosine kinases are either receptor molecules, which contain transmembrane and extracellular domains, or nonreceptor proteins, which are located intracellularly. One family of nonreceptor TKs includes the genes TEC (MIM 600583), TXK (MIM 600058), ITK (MIM 186973), and BTK (MIM 300300). All of these proteins are homologs of the Drosophila Src28 TK and contain an SH3 and SH2 domain upstream of the TK domain.[supplied by OMIM]
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UniProt Summary:
FUNCTION: SwissProt: P51813 # Activity is required for interleukin 6 (IL-6) induced differentiation. May play a role in the growth and differentiation of hematopoietic cells. May be involved in signal transduction in endocardial and arterial endothelial cells.COFACTOR: Binds 1 zinc ion per subunit (By similarity).SIZE: 675 amino acids; 78011 Da SUBUNIT: Interacts with RUFY1 and RUFY2.SUBCELLULAR LOCATION: Cytoplasm (Probable).TISSUE SPECIFICITY: Preferentially expressed in epithelial and endothelial cells.DOMAIN: SwissProt: P51813 SH2 domain mediates interaction with RUFY1.SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily. & Contains 1 Btk-type zinc finger. & Contains 1 PH domain. & Contains 1 protein kinase domain. & Contains 1 SH2 domain.
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Species:
Human
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Molecular Weight:
79kDa
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Brand Family:
Upstate
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Source:
expressed in Sf21 cells
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Protein Target:
Bmx
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Storage Conditions:
6 months at -70C
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Target Sub-Family:
TK
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Promotional Text:
This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service.
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Gene Symbol:
-
BMX
-
PSCTK2
-
PSCTK3
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NTK38
-
ETK
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Product Name:
Bmx, active
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Quality Assurance:
routinely evaluated by phosphorylation of Poly (Glu4-Tyr) (4:1)
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UniProt Number:
P51813
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Specific Activity:
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
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Packaging:
Also available in 250μg size as catalog # 14-499M - Call for pricing and availability.
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Entrez Gene Number:
-
NM_001721.4
-
NM_203281.1
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Purification Method:
Ni2+/NTA-agarose
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