货号：14-452

品牌：Merck Millipore

规格：1EA

目录价：￥6061.68

市场价格：￥5152.43

会员价格：￥4849.34

金山科研平台，产品价格货期咨询微信：jinshanbio Description: PDK1, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 10 µg View All» Product Overview: N-terminal, His6-tagged, recombinant human PDK1, amino acids 52-end. View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» UniProt Summary: FUNCTION: SwissProt: O15530 # Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity). Isoform 3 is catalytically inactive.SIZE: 556 amino acids; 63152 Da SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein. Note=Membrane-associated after cell stimulation leading to its translocation. Tyrosine phosphorylation seems to occur only at the plasma membrane.TISSUE SPECIFICITY: Appears to be expressed ubiquitously.PTM: Phosphorylated on tyrosine and serine/threonine. Phosphorylation on Ser-241 in the activation loop is required for full activity. PDK1 itself can autophosphorylate Ser-241, leading to its own activation.SIMILARITY: SwissProt: O15530 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDK1 subfamily. & Contains 1 PH domain. & Contains 1 protein kinase domain. View All» Species: Human View All» Molecular Weight: 59kDa View All» Brand Family: Upstate View All» Source: Human PDK1 expressed by baculovirus in Sf21 insect cells View All» Protein Target: PDK1 View All» Presentation: 50mM Tris-HCl, pH 7.5, 0.15M NaCl, 0.1mM EGTA, 0.03% Brij-35, 0.1% 2-mercaptoethanol, 1mM benzamidine, 200μM PMSF and 5% glycerol View All» Storage Conditions: 6 months at -70°C View All» Target Sub-Family: AGC View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Gene Symbol:

• PDPK1

• MGC20087

• PDK1

• PkB-like

• PRO0461

• MGC35290

• hPDK1
  View All» Product Name: PDK1, active View All» Quality Assurance: Routinely evaluated by phosphorylation of PDKtide View All» UniProt Number: O15530 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Packaging: Also available in 250 µg size --call for pricing and availability and reference catalog number 14-452M when ordering the 250 µg size. View All» Entrez Gene Number:
  • NM_002613.3

  • NM_031268.4
    View All» Purification Method: Ni²⁺/NTA-agarose View All»
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