货号：14-448

品牌：Merck Millipore

规格：10Ug

目录价：￥6586.00

市场价格：￥5598.10

会员价格：￥5268.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Cdk2/Cyclin A, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 10 µg View All» Product Overview: C-terminal His6-tagged human full length cdk2, and N-terminal GST-tagged human full length cyclin A View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported. View All» UniProt Summary: FUNCTION: SwissProt: P24941 # Involved in the control of the cell cycle. Interacts with cyclins A, B1, B3, D, or E. Activity of CDK2 is maximal during S phase and G2.SIZE: 298 amino acids; 33930 Da SUBUNIT: Found in a complex with CABLES1, CCNA1 and CCNE1. Interacts with CABLES1 (By similarity). Interacts with UHRF2. Part of a complex consisting of UHRF2, CDK2 and CCNE1. Interacts with the Speedy/Ringo proteins SPDYA and SPDYC. Found in a complex with both SPDYA and CDKN1B/KIP1.SIMILARITY: SwissProt: P24941 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. & Contains 1 protein kinase domain. View All» Species: Human View All» Molecular Weight: 35kDa View All» Brand Family: Upstate View All» Source: expressed individually by baculovirus in Sf21 insect cells View All» Protein Target: CDK2/cyclinA View All» Storage Conditions: 6 months at -70°C View All» Target Sub-Family: CMGC View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Replaces: 14-407 View All» Gene Symbol:

• CDK2

• p33(CDK2)
  View All» Product Name: Cdk2/Cyclin A, active View All» Quality Assurance: routinely evaluated by phosphorylation of Histone H1 View All» UniProt Number: P24941 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Packaging: Also available in 250μg size, please inquire for pricing and availability. View All» Entrez Gene Number:
  • NM_001798.2

  • NM_052827.1
    View All» Purification Method: The cdk2 is purified by Ni2+/NTA agarose and then activated using CAK and repurified by Q Sepharose™ and Ni2+/NTA agarose. The cyclin A is purified using glutathioneagarose View All»
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