货号：14-441M

品牌：Merck Millipore

规格：1ea

目录价：￥42566.00

市场价格：￥36181.10

会员价格：￥34052.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Fyn, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 250 µg View All» Product Overview: N-Terminal His6-tagged, recombinant, full-length, human Fyn. View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. View All» UniProt Summary: FUNCTION: SwissProt: P06241 # Implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels, with isoform 2 showing the greater ability to mobilize cytoplasmic calcium in comparison to isoform 1. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Blocks axon outgrowth and attraction induced by NTN1 by phosphorylating its receptor DDC.COFACTOR: Manganese.SIZE: 537 amino acids; 60762 Da SUBUNIT: Associates through its SH3 domain, to the p85 subunit of phosphatidylinositol 3-kinase. Interacts with the FYN-binding protein (FYB). Interacts with phosphorylated TOM1L1. Interacts with CD79A upon activation of the B-cell antigen receptor which increases FYN activity (By similarity). Interacts with PAG1.SUBCELLULAR LOCATION: Cell membrane. Note=Present and active in lipid rafts. Present in cell body and along the process of mature and developing oligodendroyctes.TISSUE SPECIFICITY: Isoform 1 is highly expressed in the brain, isoform 2 is expressed in cells of hemopoietic lineages, especially T lymphocytes.SIMILARITY: SwissProt: P06241 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. & Contains 1 protein kinase domain. & Contains 1 SH2 domain. & Contains 1 SH3 domain. View All» Species: Human View All» Molecular Weight: 61.8kDa View All» Brand Family: Upstate View All» Source: Human Fyn, expressed by baculovirus in Sf21 insect cells View All» Protein Target: Fyn View All» Storage Conditions: 6 months at -70°C View All» Target Sub-Family: TK View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Gene Symbol:

• FYN

• p59-Fyn

• MGC45350

• SYN

• SLK
  View All» Product Name: Fyn, active View All» Quality Assurance: Routinely evaluated by phosphorylation of the Src substrate peptide View All» UniProt Number: P06241 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Packaging: Also available in 10 μg size (cat#14-441) and in bulk (cat# 14-441-K). View All» Entrez Gene Number:
  • NM_002037.3

  • NM_153047.1

  • NM_153048.1
    View All» Purification Method: Ni²⁺/NTA-agarose View All»
    © 金山科研平台是专业的授权总代理区域代理经销平台。
    © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
    © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
    © 本文地址：https://16ao.com/thread-140595.htm
    © Merck Millipore代理14-441M Fyn Protein, active, 10 µg;store at -80℃，产品报价联系微信jinshanbio