货号：14-435

品牌：Merck Millipore

规格：

目录价：￥4891.00

市场价格：￥4157.35

会员价格：￥3912.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: DYRK1A, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 10 µg View All» Product Overview: Recombinant rat DYRK1A, corresponding to N-terminal amino acid residues 1-499, containing an N-terminal GST-tag View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. View All» UniProt Summary: FUNCTION: SwissProt: Q13627 # May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.SIZE: 763 amino acids; 85584 Da SUBUNIT: Interacts with RANBP9.SUBCELLULAR LOCATION: Nucleus speckle.TISSUE SPECIFICITY: Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney.DEVELOPMENTAL STAGE: Expressed in the developing central nervous system.PTM: Autophosphorylated on tyrosine residues.DISEASE:SwissProt: Q13627 # Overexpressed 1.5-fold in fetal Down syndrome brain.SIMILARITY: SwissProt: Q13627 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. & Contains 1 protein kinase domain. View All» Species: Rat View All» Molecular Weight: 90kDa View All» Brand Family: Upstate View All» Source: expressed in E. coli View All» Protein Target: DYRK1A View All» Storage Conditions: 6 months at -20C View All» Target Sub-Family: CMGC View All» Gene Symbol:

• DYRK1A

• HP86

• DYRK

• DYRK1

• MNBH

• hMNB

• MNB
  View All» Product Name: DYRK1A, active View All» Quality Assurance: routinely evaluated by phosphorylation of 50mM Woodtide substrate peptide View All» UniProt Number: Q13627 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Packaging: Also available in 250 µg size --call for pricing and availability and reference catalog number 14-435M when ordering the 250 µg size. View All» Entrez Gene Number:
  • NM_001396.3

  • NM_101395.2

  • NM_130436.2

  • NM_130437.2

  • NM_130438.2
    View All» Purification Method: GSH-agarose chromatography View All»
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