货号：14-415

品牌：Merck Millipore

规格：300Ug

目录价：￥8163.00

市场价格：￥6938.55

会员价格：￥6530.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Ral Assay Reagent (Ral BP1, agarose) View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 300 µg View All» Product Overview: GST fusion-protein, corresponding to residues 397-519 of rat Ral binding protein (RalBP1) bound to agarose. Also referred to as RLIP and RLP; specifically binds to and precipitates RalA-GTP and RalB-GTP from cell lysates. View All» Key Applications: Affinity Binding Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» UniProt Summary: FUNCTION: SwissProt: Q15311 # Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDC2 to switch off endocytosis, One of its substrates would be EPN1/Epsin.SIZE: 655 amino acids; 76063 Da SUBUNIT: Interacts with the GTP-bound form of RALA, RALB, CDC42 and RAC1. Interacts with REPS1 and REPS2 and this does not affect the Ral-binding activity. Interacts with DAB2IP. Interacts with catalytically active CCNB1 and CDC2 during mitosis. Interacts with EPN1, NUMB and TFAP2A during interphase and mitosis.SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein.TISSUE SPECIFICITY: Expressed ubiquitously but at low levels. Shows a strong expression in the erythrocytes.SIMILARITY: SwissProt: Q15311 ## Contains 1 Rho-GAP domain. View All» Species: Rat View All» Brand Family: Upstate View All» Source: Expressed in E. coli. View All» Presentation: 300 μg of protein in 600 μL of a 50% agarose slurry in 50 mM Tris, pH 7.5, 200 mM NaCl, 1% Triton X-100, 20 μM PMSF, 1 mM aprotinin prior to the addition of glycerol to 50%. Liquid suspension. View All» Storage Conditions: 1 year at -20°C View All» Gene Symbol:

• RALBP1

• RLIP1

• RIP1

• RalBP1

• RIP

• RLIP76
  View All» Product Name: Ral Assay Reagent (Ral BP1, agarose) View All» Quality Assurance: Routinely evaluated by Affinity Precipitation/Immunoblot Analysis View All» UniProt Number: Q15311 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Entrez Gene Number: NM_006788.3 View All»
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