货号：14-391

品牌：Merck Millipore

规格：EA

目录价：￥39480.00

市场价格：￥33558.00

会员价格：￥31584.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: MKP-1/CL100, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 500 units View All» Product Overview: GST-fusion protein containing full-length, human MKP-1/CL-100/HVH1 View All» Key Applications: Phosphatase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. View All» UniProt Summary: FUNCTION: SwissProt: P28562 # Dual specificity phosphatase that dephosphorylates MAP kinase ERK2 on both 'Thr-183' and 'Tyr-185'.SIZE: 367 amino acids; 39298 Da TISSUE SPECIFICITY: Expressed at high levels in the lung, liver placenta and pancreas. Moderate levels seen in the heart and skeletal muscle. Lower levels found in the brain and kidney.SIMILARITY: SwissProt: P28562 ## Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. & Contains 1 rhodanese domain. & Contains 1 tyrosine-protein phosphatase domain. View All» Species: Human View All» Molecular Weight: 76kDa View All» Brand Family: Upstate View All» Source: expressed in E. coli View All» Protein Target: MKP-1/CL100 View All» Storage Conditions: 6 months at -70C View All» Target Sub-Family: Ser/Thr/Tyr phosphatase View All» Gene Symbol:

• DUSP1

• HVH1

• MKP1

• MKP-1

• VH1

• YVH1

• PTPN10

• CL100
  View All» Product Name: MKP-1/CL100, active View All» Quality Assurance: routinely evaluated by dephosphorylation of 3-o-methylfluorescein phosphate View All» UniProt Number: P28562 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Entrez Gene Number: NM_004417.2 View All» Purification Method: Glutathione agarose affinity chromatography View All»
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