货号：14-383

品牌：Merck Millipore

规格：650Ug

目录价：￥6959.00

市场价格：￥5915.15

会员价格：￥5567.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Rho Assay Reagent (Rhotekin RBD, agarose) View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 650 µg View All» Product Overview: GST-tagged fusion protein, corresponding to residues 7-89 of mouse Rhotekin Rho Binding Domain, expressed in E.coli and bound to glutathione-agarose. Specifically binds to and precipitates GTP-Rho, but not GDP-Rho from cell lysates. View All» Key Applications: Affinity Binding Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. View All» UniProt Summary: FUNCTION: SwissProt: Q9BST9 # Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures.SIZE: 563 amino acids; 62667 Da SUBUNIT: Interacts via its C-terminal region with the TAX1BP3 PDZ domain. This interaction facilitates Rho-mediated activation of the c-Fos serum response element (SRE). Interacts with SEPT9. Specifically binds to GTP-bound RHOA, RHOB and RHOC and inhibits their GTPase activity.TISSUE SPECIFICITY: Highly expressed in prostate, moderately in kidney, heart, brain, spleen, testis, placenta, small intestine, pancreas, skeletal muscle and peripheral blood leukocytes, and weakly in ovary, colon and thymus. Weakly expressed in all normal cell lines tested. Overexpressed in various cancer cell lines.SIMILARITY: SwissProt: Q9BST9 ## Contains 1 PH domain. & Contains 1 REM (Hr1) repeat. View All» Species: Mouse View All» Brand Family: Upstate View All» Source: Expressed in E. coli View All» Presentation: 650 µg of recombinant protein in 1 mL glutathione-agarose slurry containing 45mM TRIS, pH 7.5, 0.45% Triton X-100, 135mM NaCl, 4.5mM MgCl2, 0.9mM dithiothreitol, 0.09mM PMSF, 0.9 µg/mL aprotinin, 0.9 µg/mL leupeptin, and 10% glycerol. View All» Storage Conditions: Stable for 6 months at -70°C from date of receipt. View All» Gene Symbol:

• RTKN

• Rhotekin.

• rhotekin

• B5
  View All» Product Name: Rho Assay Reagent (Rhotekin RBD, agarose) View All» Quality Assurance: Routinely evaluated by precipitating GTP-Rho from 3T3/A31 lysates, subsequent detection by immunoblot analysis using Anti-RhoA, clone 55 (05-778). View All» UniProt Number: Q9BST9 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Entrez Gene Number:
  • NM_001015055.1

  • NM_001015056.1

  • NM_033046.2
    View All»
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    © Merck Millipore代理14-383 Rho Assay Reagent (Rhotekin RBD, agarose), 650 µg;Rho检测试剂（Rhotekin RBD，琼脂糖），650 µgstore at -80℃，产品报价联系微信jinshanbio