货号：14-352M

品牌：Merck Millipore

规格：250Ug

目录价：￥41939.00

市场价格：￥35648.15

会员价格：￥33551.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Raf-1 (truncated), active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 250 µg View All» Product Overview: N-terminal GST-tagged recombinant human Raf-1 residues 306-end, containing the mutations Y340D and Y341D View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: Raf-1 is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. [Contributed text] View All» UniProt Summary: FUNCTION: SwissProt: P04049 # Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. Part of the Ras-dependent signaling pathway from receptors to the nucleus. Protects cells from apoptosis mediated by STK3.COFACTOR: Binds 2 zinc ions per subunit.SIZE: 648 amino acids; 73052 Da SUBUNIT: Interacts with Ras proteins. The interaction with Ras is antagonized by RIN1. Weakly interacts with RIT1 (By similarity). Interacts with STK3, which inhibits its pro-apoptotic activity.PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.SIMILARITY:SwissProt: P04049 ## Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. & Contains 1 phorbol-ester/DAG-type zinc finger. & Contains 1 protein kinase domain. & Contains 1 RBD (Ras-binding) domain. View All» Species: Human View All» Molecular Weight: 65kDa View All» Brand Family: Upstate View All» Source: Expressed by baculovirus in Sf21 insect cells View All» Protein Target: c-RAF View All» Storage Conditions: 1 year at -70°C View All» Target Sub-Family: TKL View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Gene Symbol:

• RAF1

• C-RAF

• cRaf

• Raf-1

• c-Raf

• CRAF

• RAF
  View All» Product Name: Raf-1 (truncated), active View All» Quality Assurance: routinely evaluated by phosphorylation of MBP (Catalog # 13-104) substrate in vitro View All» UniProt Number: P04049 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Packaging: Also available in 10 μg size (cat#14-352) and in bulk (cat# 14-352-K). View All» Entrez Gene Number: NM_002880.2 View All» Purification Method: Glutathione agarose affinity chromatography View All»
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