货号：14-330

品牌：Merck Millipore

规格：50Ug

目录价：￥5200.00

市场价格：￥4420.00

会员价格：￥4160.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: JNK2α2/SAPK1a, unactive View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 50 µg View All» Product Overview: N-terminal His6-tagged, recombinant, full-length, human JNK2α2/SAPK1a unactive View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. View All» UniProt Summary: FUNCTION: SwissProt: P45984 # JNK2 isoforms display different binding patterns: alpha- 1 and alpha-2 preferentially bind to c-Jun, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.COFACTOR: Magnesium.SIZE: 424 amino acids; 48139 Da SUBUNIT: Binds to at least four scaffolding proteins, MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK8IP3/JIP-3/JSAP1 and SPAG9/MAPK8IP4/JIP-4. These proteins also bind other components of the JNK signaling pathway.DOMAIN: SwissProt: P45984 The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.PTM: Dually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme. Autophosphorylated in vitro.SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. & Contains 1 protein kinase domain. View All» Species: Human View All» Molecular Weight: 49.2kDa View All» Brand Family: Upstate View All» Source: Expressed in Sf21 insect cells View All» Protein Target: JNK2α2/SAPK1a View All» Storage Conditions: 1 year at -20°C View All» Target Sub-Family: CMGC View All» Gene Symbol:

• MAPK9

• JNK2B

• JNK-55

• JNK2

• JNK2BETA

• p54aSAPK

• JNK2ALPHA

• PRKM9

• JNK2A
  View All» Product Name: JNK2α2/SAPK1a, unactive View All» Quality Assurance: Routinely evaluated by phosphorylation of JNK2α2/SAPK1a View All» UniProt Number: P45984 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Entrez Gene Number:
  • NM_002752.3

  • NM_139068.1

  • NM_139069.1

  • NM_139070.1
    View All» Purification Method: Ni²⁺/NTA-agarose View All»
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