货号:14-278
品牌:Merck Millipore
规格:600Ug
目录价:¥7648.00
市场价格:¥6500.80
会员价格:¥6118.40
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Description:
Ras Assay Reagent (Raf-1 RBD, agarose)
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Trade Name:
Upstate (Millipore)
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Qty/Pk:
600 µg
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Product Overview:
GST fusion-protein, corresponding to Ras Binding Domain of Raf-1, provided bound to glutathione agarose.
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Key Applications:
Enzyme Assay
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Entrez Gene Summary:
Members of the RAS superfamily of GTP-binding proteins, which includes MRAS, are membrane-anchored, intracellular signal transducers responsible for a variety of normal cellular functions. They are oncogenically activated in a significant fraction of tumors.[supplied by OMIM]
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UniProt Summary:
FUNCTION: SwissProt: O14807 # May serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Weakly activates the MAP kinase pathway.SIZE: 208 amino acids; 23846 Da SUBUNIT: Interacts with RGL3 (By similarity).SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential).TISSUE SPECIFICITY: Expression highly restricted to the brain and heart.SIMILARITY: SwissProt: O14807 ## Belongs to the small GTPase superfamily. Ras family.
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Species:
Human
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Brand Family:
Upstate
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Source:
Human Ras Binding Domain (RBD, residues 1-149) of Raf-1, expressed in E. coli.
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Storage Conditions:
1 year at -20°C
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Promotional Text:
This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service.
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Gene Symbol:
-
MRAS
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RRAS3
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M-RAS
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FLJ42964
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R-RAS3
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M-RAs
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Product Name:
Ras Assay Reagent (Raf-1 RBD, agarose)
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Quality Assurance:
Routinely evaluated by Affinity Precipitation/Immunoblot Analysis
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UniProt Number:
O14807
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Specific Activity:
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
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Entrez Gene Number:
-
NM_001085049.1
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NM_012219.3
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