货号：12-556

品牌：Merck Millipore

规格：EA

目录价：￥3920.00

市场价格：￥3332.00

会员价格：￥3136.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Cofilin 1 View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 150 µg View All» Product Overview: N-terminal GST-tagged recombinant human, full length cofilin 1 View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: P23528 # Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods.SIZE: 166 amino acids; 18502 Da SUBCELLULAR LOCATION: Nucleus matrix. Cytoplasm, cytoskeleton. Note=Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide.TISSUE SPECIFICITY: Widely distributed in various tissues.PTM: Phosphorylated on Ser-3 in resting cells (By similarity).SIMILARITY: SwissProt: P23528 ## Belongs to the actin-binding proteins ADF family. & Contains 1 ADF-H domain. View All» Species: Human View All» Molecular Weight: 44.9kDa View All» Brand Family: Upstate View All» Source: expressed in E. coli View All» Storage Conditions: 1 year at -20°C View All» Gene Symbol:

• CFL1

• CFL

• Cofilin-1

• p18
  View All» Product Name: Cofilin 1 View All» Quality Assurance: Routinely evaluated as a substrate in a kinase assay using LIM Kinase 1 (Catalog# 14-656). View All» UniProt Number: P23528 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Entrez Gene Number: NM_005507.2 View All» Purification Method: Glutathione-agarose View All»
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