金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: TC-PTP Long Name: T Cell Protein Tyrosine Phosphatase Aliases: PTP2; PTPN2 Entrez Gene IDs: 5771 (Human); 19255 (Mouse) Background: TC-PTP T cell protein tyrosine phosphatase (TC-PTP), also known as PTPT and PTPN2, is an enzyme that removes phosphate groups covalently attached to tyrosine residues in proteins. TC-PTP dephosphorylates a wide range of phosphoproteins, such as p52Shc and receptors for EGF, Insulin and Growth Hormone. Although found in many cell types and tissues, TC-PTP is particulary prominent in hemopoietic cell types. Knockout mice lacking TC-PTP are born viable but die 3 to 5 weeks after birth of erythropoietic and lymphopoietic deficits, indicating a critical role for TC-PTP in bone marrow maturation.