金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: SHP-2 Long Name: Src Homology Region 2 Domain Phosphatase 2 Aliases: PTP1D; PTP2C; PTPN11; SH-PTP2 Entrez Gene IDs: 5781 (Human); 54390 (Mouse); 25622 (Rat) Background: SHP-2 The SH2 domain-containing phosphatases, SHP-1 and SHP-2, are well-studied cytosolic tyrosine phosphatases that share many structural and regulatory features. They both have two tandem SH2 domains at the N-terminus, followed by a catalytic domain, and an inhibitory C-terminus. Despite their structural similarity, the enzymes appear to have different physiological roles and exhibit different expression patterns. SHP-1 is highly expressed in hematopoietic tissues, and in general has a negative impact on lymphocyte signaling. In contrast, SHP-2 is widely expressed, and in general promotes signaling pathways that lead to differentiation, cell growth, or migration.