金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: GFR alpha-4/GDNF R alpha-4 Long Name: Glial Cell line-derived Neurotrophic Factor Receptor alpha 4 Aliases: GDNF R alpha-4; GFRA4 Entrez Gene IDs: 64096 (Human); 14588 (Mouse) Background: GFR alpha-4 GFR alpha -1, -2, -3, and -4 are GPI-anchored receptors that interact preferentially with the GDNF family ligands GDNF, Neurturin, Artemin, and Persephin, respectively. GFR alpha proteins initiate signaling in association with the receptor tyrosine kinase RET and by RET-independent pathways. GFR alpha-mediated signaling is instrumental in the differentiation, migration, and support of central and peripheral neurons. Alternative splicing generates multiple isoforms of GFR alpha proteins.