金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: PTP1B Long Name: Protein Tyrosine Phosphatase 1B Aliases: PTPN1 Entrez Gene IDs: 5770 (Human); 19246 (Mouse) Background: PTP1B (Protein Tyrosine Phosphatase 1B) Protein tyrosine phosphatase 1B (PTP1B) dephosphorylates tyrosine residues on several proteins including c-Src, beta-catenin, and the receptors for insulin and epidermal growth factor. PTP1B knock-out mice are resistant to high-caloric intake-induced obesity and have exaggerated insulin responses, suggesting that PTP1B may play a role in regulating growth factor responsiveness.