R&D Systems代理AB-270-NA Human CCL3/MIP-1 alpha Polyclonal Ab (1 MG)-试剂-金山科研平台

R&D Systems代理AB-270-NA Human CCL3/MIP-1 alpha Polyclonal Ab (1 MG)

2025-06-25

货号：AB-270-NA

品牌：R&D Systems

规格：1mg

目录价：￥5180.00

市场价格：￥4144.00

会员价格：￥4144.00

到货时间：3~4周

金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: CCL3/MIP-1 alpha Aliases: LD78a; MIP-1 alpha Entrez Gene IDs: 6348 (Human); 20302 (Mouse); 25542 (Rat); 448787 (Canine) Background: CCL3/MIP-1 alpha

View MIP-1 alpha IHC images. MIP-1 alpha (macrophage inflammatory protein 1 alpha) is a member of the CC or beta chemokine subfamily that was originally purified from the conditioned media of an LPS-stimulated murine macrophage cell line. MIP-1 alpha acts as a chemoattractant to a variety of cells including monocytes, T cells, B cells and eosinophils.

The two human MIP-1 alpha genes arise by duplication/mutation. They code for MIP-1 alpha isoforms CCL3/LD78a and CCL3L1/LD78b, which share 94% amino acid sequence homology. Whereas the human CCL3/LD78a is a single-copy gene, the human CCL3L1/LD78b gene copy number varies within the population. Human CCL3L1/LD78b binds and signals through chemokine receptors CCR1, CCR5. When compared to CCL3/LD78a, CCL3L1/LD78b has higher binding affinity to CCR5, which also functions as a coreceptor for HIV-1 entry. The copy number of CCL3L1 is one of several genetic determinants of HIV-1 susceptibility.

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