金山科研平台，产品价格货期咨询微信：jinshanbio Source:Mouse myeloma cell line, NS0-derived, Phe20-Asn469 Accession #:P03956 N-terminal Sequence Analysis:Phe20 Structure:Pro form Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Endotoxin Level: Predicted Molecular Mass:52kDa SDS-PAGE:52-55kDa, reducing conditions Activity:Measured by its ability to cleave a fluorogenic peptide substrate Mca-KPLGL-Dpa-AR-NH₂ (Catalog# ES010).The specific activity is >400pmol/min/µg, as measured under the described conditions. Formulation:Supplied as a 0.2 µm filtered solution in MES, NaCl, CaCl₂ and Brij-35.See Certificate of Analysis for details. Molecule Information: MMP-1 Long Name: Matrix Metalloproteinase 1 Entrez Gene IDs: 4312 (Human) Background: MMPs (Matrix Metalloproteinases)

The matrix metalloproteinases (MMPs) consist of 24 known human zinc proteases with essential roles in breaking down components of the extracellular matrix (ECM). Additional MMP substrates include cytokines, chemokines, growth factors and binding proteins, cell/cell adhesion molecules, and other proteinases. With a few exceptions, MMPs share common structural motifs including a pro-peptide domain, a catalytic domain, a hinge region, and a hemopexin-like domain. Synthesized as pro-enzymes, most MMPs are secreted before conversion to their active form. MMP activities are modulated on several levels including transcription, pro-enzyme activation, or by their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs). A subset of MMPs are associated with membranes and designated as membrane-type metalloproteinases (MT-MMP).