金山科研平台，产品价格货期咨询微信：jinshanbio Source:E. coli-derived, Ala2-Asp211, with a C-terminal 10-His tag Accession #:P10415 N-terminal Sequence Analysis:Ala2 Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Endotoxin Level: Predicted Molecular Mass:24.5 kDa SDS-PAGE:27 kDa, under reducing and non-reducing conditions Activity:Measured by its ability to inhibit Caspase-8-cleaved BID-mediated release of cytochromec from isolated mouse liver mitochondria using the Rat/Mouse Cytochrome c Quantikine ELISA (Catalog# MCTC0) to quantify cytochromec.The typical EC₅₀ is less than 500nM in the presence of 54nM Recombinant Human BID Caspase-8-cleaved (Catalog# 882-B8). Optimal dilutions should be determined by each laboratory for each application. Formulation:Supplied as a 0.2 µm filtered solution in HEPES, KCl and Glycerol.See Certificate of Analysis for details. Molecule Information: Bcl-2 Long Name: B Cell Lymphoma/Leukemia 2 Entrez Gene IDs: 596 (Human); 12043 (Mouse); 24224 (Rat) Background: Bcl-2 View Bcl-2 IHC images. Bcl-2 is a member of a family of proteins that regulates outer mitochondrial membrane permeability. Bcl-2 is an anti-apoptotic member that prevents release of cytochrome c from the mitochondria intermembrane space into the cytosol. Bcl-2 is present on the outer mitochondrial membrane and is also found on other membranes in some cell types. Natural Bcl-2 contains a carboxyl-terminal mitochondria targeting sequence.